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In several RCTs, GLP-1RAs, when used alone or in combination with other hypoglycemic agents including metformin, sulfonylurea, DPP-4 inhibitor, thiazolidinedione, and sodium-glucose cotransporter 2 inhibitor, showed superior or non-inferior blood glucose lowering ability compared to insulin treatment [64,65]

It remains to be determined whether this effect extends to other substrates and cell types

An alternative approach could be to lower the oxidative damage by lowering the free radical produced as the rods die

AdipoRon protects against secondary brain injury after intracerebral hemorrhage via alleviating mitochondrial dysfunction: Possible involvement of AdipoR1AMPKPGC1 pathway

15 , eabq5858 (2023)