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Insulin use was reported for 34.6% of patients 180 days before the index date, and 62.1% had used either one or two medications in a GLD class other than GLP-1 RA, most often metformin (50.4%)

Peptide identifications were validated using a 1% false discovery rate threshold calculated with the Percolator algorithm

The unregulated peptide market has documented contamination issues

Chronic neuroinflammation is increasingly recognized as a significant contributor to HD pathogenesis

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DIA data mining heavily relies on a spectral library that in most cases is built on DDA analysis of the same sample