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Preclinical studies indicate that Daidzein, Biochanin A, Formononetin, and Tectorigenin inhibit ferroptosis and have been applied in APAP-induced hepatotoxicity, knee osteoarthritis, chronic kidney disease, and ureteral obstruction

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Mitochondrial biogenesis is only advantageous if mitochondria are functional We examined mitochondrial staining by TOM20 immunohistochemistry in HCT116 xenografts and AKP orthotopic tumours treated with 5FU and/or metformin