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46 There is a relationship between HFpEF and obesity, with the latter considered not only a significant comorbidity but also a direct contributor to HFpEF
Retatrutide and newer agents Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously
Diabetes Res Clin Pract (2013) 100:e669
Doyon, C., Fortin, R
The third mechanism whereby diabetes upregulates ANGII/AT1R is ACE2 downregulation, resulting in local ANG (1-7) reduction and, consequently, in an imbalance of the RAS
doi:10.1111/1468-0009.12693
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