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By activating both GLP-1 and GIP receptors, tirzepatide offers a broader metabolic impact
The effects are not limited to any specific area
For example, when leptin levels are reduced, POMC expression is also reduced and NPY expression is increased (149)
See also: ipamorelin regulatory status for the country-by-country approvals picture
Large observational studies have found that GLP-1 receptor agonists are associated with a lower risk of non-candida urinary tract infections compared to SGLT2 inhibitors, with a hazard ratio of 0.91 or lower and statistical significance below 0.001
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