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The breadth of the development program reflects confidence in the Phase 2 results and suggests that retatrutide, if approved, will be positioned as a comprehensive metabolic therapy rather than simply a weight loss drug
New England Journal of Medicine 2025;392:2001-12
Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models
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