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Prior studies showed that 17-estradiol protects neurons from developing IR, and that ovarian hormones also contribute to regulate phosphorylation of IRS-1 [78]

doi: 10.1080/15548627.2021.1962681 35 ZhengZChenJXueXMaXZhangSWangMet al

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Its explanation is that these are potent agents that lower blood glucose, reduce appetite, and slow gastric emptying, and that they carry risks serious enough to require prescriber oversight and baseline screening before anyone begins

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