Last year, this rash blew up when I was in Bora Bora, and I realized something was wrong
The synthesis initiated with the direct chlorination of Compound 35 , yielding chloroindane methyl ester 36 , which, after chiral resolution using HPLC, afforded Compound 32 (Scheme 5) (Humphrey, 2014)
This reaction also requires nitrogen protection
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Wu Y, Jiang Y, Gong Y, Yao T, Zheng Q, Li Y, Xia Q, Li B, Li L (2025) A Janus structured nanoclay microgel system for targeted probiotic therapy in diarrhea-predominant irritable bowel syndrome