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Pfizers $10B bet implies the company believes these eventualities are manageable or that the benefits (market share, IP, platform) outweigh risks
However, due to food processing, heating and storage, the MSM content in food decreases rapidly, which is why supplementation may be interesting for many people
Because of this low oral bioavailability, clinical formulations of ALCAR must be dosed high enough to ensure that an adequate amount of the active compound survives the digestive process and reaches the blood-brain barrier
doi:10.2460/javma.2002.220.1315
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