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Glutamine in cancer cells plays critical and diverse roles by providing not only a source of nitrogen for amino acid and nucleotide biosynthesis but also a source of carbon to replenish the tricarboxylic acid (TCA) cycle and lipid biosynthesis pathways
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This activity mediates the differentiation of CD4 + T cells into Th1 and Th17 subtypes, promoting the production of inflammatory factors such as IFN- and IL-17, and shifting their metabolic profile from oxidative phosphorylation to glycolysis [392]
A lot of people that I talked to while I was reporting seemed to think that because there are so many exciting new use cases that are being discovered, there's a world where this drug will go on and off the shortage list repeatedly, indefinitely
Researchers are responsible for ensuring that all downstream uses fall within their institutions approved protocols and applicable regulatory framework
doi: 10.1007/s12275-013-3168-8 70 RahnamaM.MacleanP.FleetwoodD
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