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Favourable changes in cardiometabolic markers were also reported in the Phase 2 trial data, including reductions in: Systolic blood pressure Triglyceride levels Waist circumference (a proxy for visceral adiposity) However, these are surrogate markers and should not be interpreted as evidence of a reduction in major adverse cardiovascular events (MACE)

10 th ed: John Wiley & Sons, Inc

Menardo J, Tang Y, Ladrech S, Lenoir M, Casas F, Michel C, Bourien J, Ruel J, Rebillard G, Maurice T, Puel JL, Wang J

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If both medications are used together, doctors usually use this combination for a short period under close medical supervision and regularly assess safety and progress

In a longitudinal study of such patients, mean pro-C3 increased with worsening of fibrosis and decreased with fibrosis improvement 36