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It was found that CB-839 could synergize with other anticancer drugs to exert beneficial therapeutic effects, and KRAS mutation led to enhanced glucose and glutamine metabolism in ovarian cancer cells, which was better inhibited by the combination of metformin and CB-839 [32]

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In bovine species, fertilization rates tend to remain relatively low, highlighting the need for improvements in the developmental competence of cryopreserved oocytes []