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Anxiety-like behavior In rats, supplementation with HFD (G0-P21 [137] and P20-84 [134], a high-fat-high-sugar diet (P21-91) [138], palatable diet (P21-P60) [139] or highly palatable food diet (P28-56 [133] and P22-59 [136] and P20-84 [135]) reversed the POS - induced anxiety-like behavior as measured in the OFT at M4-7 [137] and P54-59 [133, 136], in the EPM between W10-12 [134, 138], P60-P67 [139] and at P54-59 [133] and in the LDB at W10-12 [134] and at P34-84 in females [135]

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TRICARE requires documented trial and failure (or contraindication) of: Metformin (unless contraindicated due to renal function or intolerance) At least one additional oral agent (sulfonylurea, SGLT2 inhibitor, or DPP-4 inhibitor) Duration of trial: minimum 90 days per agent at therapeutic dose Step 3: Review and determination

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doi:10.1111/jocd.15869