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The PRMT5 inhibitor PF-06939999 inhibited the proliferation of non-small cell lung cancer (NSCLC) in cells and animal models and dose-dependent reduced symmetrical dimethylarginine (SDMA) levels

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10 Finally, major surgery (eg, removal or replacement of all or part of the bladder, and/or rerouting of the urinary stream) can be effective but has a high complication rate and is a last option for those with severe, debilitating, intractable symptoms

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Advanced symptoms may also include cardiovascular problems

Cell 183, 94109.e123