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Oral delivery and reduced dosing frequency are emerging differentiators that aim to improve adherence and therefore real-world outcomes. 1 Broader Drugs to Watch in 2026 Pipeline Span Oncology, Immunology, and Rare Disease Among the 11 drugs cited in the Clarivate report, no other medications were projected to exceed more than $2 billion in 2031

Ozempic (semaglutide) is a GLP-1 receptor agonist that produces significant appetite suppression and slows gastric emptying, resulting in substantial caloric deficit-driven weight loss

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Both are mostly gastrointestinal and mostly during dose escalation

Vial G, Detaille D, Guigas B (2019) Role of mitochondria in the mechanism(s) of action of metformin