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Savikj M, Stocks B, Sato S, Caidahl K, Krook A, Deshmukh AS, et al
Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other
This simple answer is, yes, you need supplements while on a GLP-1 medication
Blood work considerations Periodic blood work provides insight into metabolic effects of multi-peptide protocols
The best choice depends on your body, your goals, and your response
