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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

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Key benefits Why people compare it 1 10 million times the synaptogenic potency of BDNF on a molar basis 2 Orally bioavailable peptidomimetic that crosses the blood-brain barrier 3 Promotes new dendritic spine formation in hippocampal CA1 neurons 4 Active at picomolar concentrations (10^-13 M) for cognitive enhancement 5 Reversed scopolamine-induced cognitive deficits in preclinical dementia models 6 Activates HGF/c-Met signaling via PI3K/Akt and Ras/MAPK cascades 7 Strengthens existing synaptic connections (long-term potentiation) 8 Protease-resistant design enables oral and subcutaneous administration Deep research About Dihexa Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a modified dipeptide analog with a molecular weight of approximately 507.63 Da