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Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments

They actually rebuild collagen stores over time, producing progressive improvement rather than mere maintenance of current state

This 6-step plan in summary: Assess labs and absorption, switch folic acid to active B forms, start low-dose methyl-folate and methylcobalamin with titration, support with protein/choline/B6/magnesium and whole foods, monitor homocysteine and symptoms, and set realistic expectations

This dual approach has the potential to enhance weight loss results through a synergistic effect