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While LTB4 acts as a strong stimulator for chemotactic aggregation of granulocytes, leukotriene-C4 and leukotriene-D4 cause the wheal and flare response (Meyers and Berk, 1990)

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For type 2 diabetes, semaglutide is initiated at 0.25 mg subcutaneously once weekly for four weeks, then increased to 0.5 mg weekly