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In the UK, changing treatment requires medical supervision and careful timing
The dose is then increased to 0.5 mg weekly, with further escalation to 1 mg and potentially 2 mg (after at least 4 weeks at each step) if additional glycaemic control is required
Rotation system Use a first-in, first-out system
On the other hand, SGLT-2is influence glucose sensing or absorption in specific neurons, and suppresses the sympathetic nervous system, thus regulating the cardiovascular activity, lowering energy expenditure, and maintaining glucose homeostasis in the pancreas and kidney (Figure 2)
To learn more, check out the recording of our webinar, GLP-1 Spotlight: Navigating Coverage, Costs, and Clinical Outcomes.
It is legally obtainable in the United States through licensed compounding pharmacies when prescribed by a medical provider for a specific patient after a clinical evaluation
