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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
Hermann, W
Site rotation importance Repeatedly injecting in the same location can cause local tissue changes including lipohypertrophy (abnormal fat accumulation) or lipoatrophy (fat loss creating depressions)
Brit Med J
Anti-Inflammatory Effects: Reduces inflammatory markers and attracts immune cells to sites of damage, coordinating the healing response
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