Serious adverse events were rare
and Vladimir Vitalievich Rafalskiy (2023)
Expert Review of Endocrinology & Metabolism, 2025) The Fertility Paradox Worth Discussing With Your Provider For patients not actively trying to conceive, restored ovulation can be an unexpected and clinically significant side effect of treatment meaning contraception planning should be part of the conversation when starting GLP-1 therapy for PCOS, not an afterthought
The drug carries a potential risk for a type of thyroid tumor, so it shouldnt be taken by people with a personal or family history of certain thyroid and endocrine tumors
Whilst training might not be a priority during this holy month, there are some considerations you might want to put into practice to ensure you maintain healthy habits and optimise any training
In the Phase 2 trial, up to half of retatrutide participants in the higher-dose groups reported these side effects