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4d), among which six ferroptosis-inhibiting genes (Slc7a11, Slc40a1, Gclm, Fth1, Gclc, and Gss) were upregulated, one ferroptosis-promoting gene (Slc39a14) was downregulated, and one ferroptosis-promoting gene (Hmox1) was upregulated

Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/SIRT1/HMGB1 signaling pathway in type 1 diabetic rats

Among these, cholesterol metabolism plays a context-dependent role in ferroptosis, with cholesterol and its intermediates either promoting or suppressing ferroptotic cell death depending on cellular and microenvironmental conditions

Chakrabarti, A

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