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However, the cytotoxic effects of MTX are not limited to cancer cells and can also affect many normal tissues including the brain (Behairy et al
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they answer different research questions, and the choice is a design decision rather than a dosing one
Experimental studies suggest possible effects involving: Nitric oxide signaling Blood vessel formation (angiogenesis) Cellular communication pathways Fibroblast migration Collagen organization Tissue remodeling after injury Fibroblasts are specialized cells responsible for producing collagen and rebuilding damaged connective tissue
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