Retatrutide adds the glucagon receptor on top of this, which appears to increase GI side effect rates above tirzepatide levels
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If you take PPIs (proton pump inhibitors), metformin, NSAIDs, or other medications that affect gut pH, motility, or the microbiome, adding Pendulum may produce unpredictable results
However, until now, robust evidence from randomized clinical trials has been limited
Al-Mashhadi ZK, Viggers R, Fuglsang-Nielsen R, Vestergaard P, Gregersen S, Starup-Linde J
If you're in the Chicago western suburbs and want comprehensive, evidence-based care from a triple board-certified endocrinologist, here's what to expect