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Moreover, instead of promoting immunity against tumours, STING activation in B cells induced the secretion of anti-inflammatory cytokine IL-35 that impeded the actions of NK cells and led to poorer outcomes in mouse models 22

Moreover, more potential molecules and traditional medicines/extracts with antioxidant activity are needed to be identified, which would lay the foundation for developing PIPN-tailored drugs

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Regulatory agencies require extensive clinical evidence before approval, and the absence of such data means safety and effectiveness remain uncertain

Sustained elevated GH and IGF-1 are the pharmacologic feature