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The primary focus of research in active DNA damage is on apoptotic DNA fragmentation, identified by DNA double-strand breaks (50)
Indeed, mutant OPG proteins expressed in co-cultured OPG-deficient osteoblasts retain their ability to bind RANKL but lack the ability to regulate RANKL transport and could not restore osteoclast formation to wild-type levels, suggesting that osteoclastogenic capacity is at least partially regulated by OPG/RANKL (Honma et al., 2013
The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells
Belonging to the Cap n collar (CNC) family of transcription factors, Nrf2 possesses a well-conserved basic region-leucine zipper (bZip) motif and binds to the antioxidant response element (ARE), or electrophile response element (EpRE
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