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Relamorelin (RM-131), a modified ghrelin peptide, was studied in phase 2 trials for diabetic gastroparesis, and macimorelin, a non-peptidyl GHS-R1a agonist, received FDA approval in December 2017 under the brand name Macrilen for the diagnosis of adult growth hormone deficiency, marking the first FDA-approved compound in the ghrelin receptor agonist class
Mitochondrial glutathione: features, regulation and role in disease
Glutathione protects cell mitochondria by removing free radicals
Pisano C, Pratesi G, Laccabue D, Zunino F, Lo Giudice P, Bellucci A, Pacifici L, Camerini B, Vesci L, Castorina M, Cicuzza S, Tredici G, Marmiroli P, Nicolini G, Galbiati S, Calvani M, Carminati P, Cavaletti G
It helps to minimise the impact of free radicals
Together, these data position histone acetylation as a dynamic regulator of stress adaptation and antidepressant responsiveness across multiple brain circuits
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