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Consistent with the non-glycaemic effects of glucagon to inhibit food intake, enhance lipid metabolism and accelerate energy expenditure [70], a single-molecule GLP-1/GCGR co-agonist improved body weight and glucose control in mice with DIO beyond that observed with GLP-1 receptor agonism alone [114, 115]
glutamate, cysteine and glycine
BMJ 381 , e073312 (2023)
Nature 476:458-461
And a GLP-1 named Wegovy secured a supplemental cardiovascular indication from the Food and Drug Administration this spring
Molecules 25, 256
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