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The Journal of Clinical Endocrinology and Metabolism
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Overall, considering the evidence reported here, the cellular antioxidant defense in ALS appears to be strongly diminished, with an imbalance towards high and persistent OS levels
However, there are disputes about the relevant applicability of this evidence [18, 19], particularly considering the low survival rate of bone marrow stromal cells transplanted into the contused adult rat spinal cord [20, 21] and the need to completely fill the lesion site with neural stem cells [22]
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Their efficacy varies across different substances, with inconsistent results observed in chronic alcohol use models
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