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Concurrently, it facilitated the phosphorylation of Smad2/3 downstream from TGF-, enhancing transduction within the TGF- signaling pathway, which subsequently promoted increased collagen content in these cells, thereby achieving significant antiphotoaging effects on the skin
Hydroquinone (HQ), another well-studied whitening agent, has been used clinically in leading cosmetic hyperpigmentation treatment 23 , however, it was also found to cause serious problems by generating reactive oxygen species leading to oxidative damage of lipids and permanent loss of melanocytes
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It has demonstrated the ability to close complex fistulas (abnormal connections between organs) by simultaneously repairing internal mucosal defects and external skin tissue