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LactMed notes that several studies on its effects on lactation are unable to offer valid conclusions because of their lack of blinding, randomization, and placebo control.48 However, there's at least one randomized control trial of particular relevance here because it used a combination of goat's rue and a silymarin phytosome

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Access to literature, institutional resources, and supporting materials cited in this work was provided through funding and support from NI Department for Education and Ulster University Research Strategic Funding

Additionally, aminorex and sibutramine have been linked to cardiovascular toxicity, pulmonary hypertension, and a rise in non-fatal cardiovascular incidents [37, 39, 43, 45, 46]

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The table below grades each available line of evidence by the strength of its underlying design