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Limitations of RCTs presented in Table 2 and Table 3 The side effects reported at the end of a clinical trial may be partially distorted due to gastrointestinal problems if the study is stopped too early [127]

treated acute colitis in a mouse model of inflammatory bowel disease using hyaluronic acid-bilirubin nanoparticles, which reinstated the epithelial barrier in the mice as well as modulating the intestinal microbiota, showing promising anti-inflammatory properties by increasing overall abundance and diversity

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Natural digestive aids like probiotics can help rebalance gut bacteria to favor strains that produce less hydrogen sulfide during protein breakdown. 5