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Tirzepatide (Zepbound) went further, with average losses of up to about 21% at the highest dose in SURMOUNT-1
Instead of continuing full therapeutic doses, the goal of maintenance is to: Keep appetite and cravings stable Support metabolic balance Prevent rapid rebound weight gain Allow your body to adjust gradually Why GLP-1 Maintenance Matters GLP-1 medications work at multiple levels: blood sugar regulation, appetite signaling, digestion speed, insulin release, and even reward-based eating patterns
Biochem Biophys Res Commun 2003
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The medical guidance remains consistent across all these medications: If pancreatitis symptoms develop, discontinue treatment right away and get emergency medical help
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