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[18] [19] Important safety considerations include: Increased risk of hypoglycaemia when combined with insulin or sulfonylureas GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors [15] [18] These medications are not recommended during pregnancy or breastfeeding You should contact your GP if you experience: Persistent symptoms of hyperglycaemia (excessive thirst, frequent urination, unexplained weight loss) despite lifestyle modifications Difficulty managing your weight despite sustained efforts with diet and exercise Symptoms suggesting complications of diabetes or metabolic syndrome Severe or persistent gastrointestinal symptoms if already taking GLP-1 medications Seek urgent medical attention if you develop severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis, or right-sided abdominal pain or yellowing of the skin/eyes which could suggest gallbladder problems

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In the epidermis, UV exposure induces keratinocyte production of MSH/ACTH, which activate MC1R on melanocytes

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