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Legal status (US): Not FDA-approved for any human indication

After opening, it is commonly used for 28 days in laboratory practice

Cooper BM, Iegre J, ODonovan DH, Halvarsson M, Spring DR (2021) Peptides as a platform for targeted therapeutics for cancer: peptidedrug conjugates (PDCs)

The axonal transport though the trigeminal or olfactory nerves is the major pathway for nose-to-brain transport and additionally, diffusional influx into the brain also contributes to this transport (Dhuria et al., 2010

Most individuals with raised serum B12 remain asymptomatic, and the elevation serves primarily as a biochemical marker that may warrant further investigation