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Using a public economic framework, Igarashi et al estimated that overweight/obesity generates an annual fiscal burden of approximately US $13.41 billion (1925 billion)around 0.4% of Japans GDPdriven by excess healthcare expenditures, reduced employment and income, increased sick leave, and higher government transfers, including pensions associated with early retirement

Compared with those in the WT group, the expression levels of these five genes were lower in the control group ( P = 0.1413, 0.0098, 0.0006, 0.0007, and 0.3512 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively), whereas the expression levels were significantly greater in the combination group than in the control group ( P = 0.0013, 0.0017, 0.0043, 0.0023, and 0.0016 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively) (Fig

Statements Author contributions RO'C: Conceptualization, Writing review & editing, Writing original draft