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This article shows that an insulin-mediated decrease of hyperglycaemia restores the insulinotropic effects of GIP

While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

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Because peptides tend to work upstream, influencing signaling pathways rather than end-organ function

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Adding more water lowers the concentration, so you will need to draw a larger volume for the same dose