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Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic -cell bioenergetic parameters and metabolism in BRIN-BD11 cells
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27 This is in contrast to exenatide, which is primarily eliminated through the kidneys, and is not recommended for use in patients with severe renal impairment or in those with end-stage renal disease (ESRD)
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