The practical consequence is that once a vial is opened and the rubber stopper has been pierced with a needle, the preservative keeps the contents safe to use for up to 28 days, provided the vial is stored correctly and the stopper is wiped with an alcohol prep pad before each draw
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An oral supplement has to travel through your digestive tract, survive stomach acid, bind to a protein called intrinsic factor, and be absorbed in the small intestine
50% of the bodys storage of vitamin B12 is kept within the liver, no matter how it is administered, so if the liver is sick, in all likelihood, a person can suffer B12 deficiency
These factors support continued research interest despite the disappointing oral efficacy results