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In mouse islets, ER induces a shift in GLP-1R coupling from Gs to Gq proteins
Bottom line: a logged step-up or missed dose gives the next clinician visit facts to work from instead of memory
Research and Development: The company continues to invest in research to better understand the drugs long-term effects and possibly develop safer alternatives or modifications to existing formulations
We [also] found that semaglutide acts via a reward area [in the brain] called nucleus accumbens. The studys main limitation is that it used rats and mice
In the STEP-UP trial, the 7.2 mg dose produced 20.7% weight loss at 72 weeks, much closer to Mounjaro 15 mg than the 2.4 mg dose tested in SURMOUNT-5
Once a peptide degrades, its efficacy is diminished or completely lost
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