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The evidence: Years of evidence have shown that in low doses, natural caffeine can sometimes improve mental performance

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Riboflavin is Required for Homocysteine Metabolism Homocysteine can either be acted upon by cystathionine b-synthase forming cystathionine and glutathione (88), requiring PLP as a cofactor, or methionine synthase forming methionine (88), requiring methyl B12 as a cofactor and 5-methyltetrahydrofolate as a methyl donor