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In April 2005 the US Food and Drugs Administration (FDA) approved a synthetic version, called exenatide, to treat type 2 diabetic patients unable to sufficiently control their blood sugar levels with other diabetic medications like metformin, and sulfonylureas

Within the ARC, two functionally opposing populations of neurons exist which co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) or POMC [133]

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