Hormones (Athens)
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Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK
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In accordance, LRP1 is required for mediating the growth inhibitory response of TGF-/Smad signaling through TGF-R I and II in smooth muscle cells (Boucher et al., 2007)