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Next review due: 4 Nov 2027 5 Nov 2024 | Latest version Last updated by Michael Stewart, MRPharmS Peer reviewed by Sid Dajani 5 Nov 2021 | Originally published Authored by: Michael Stewart, MRPharmS Ask, share, connect
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During the early stages of osteoblast differentiation, TGF- promotes the proliferation of osteoprogenitor cells and supports osteogenesis, whereas during the late stages, TGF- signaling inhibits bone formation by negatively regulating ATF4, a key osteogenesis-related transcription factor
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PMCID: PMC11091751
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