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For deeper mechanistic insights, we employed proteomic profiling and mitochondrial functional assays
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Ikarashi N, Kon R, Nagoya C, Ishikura A, Sugiyama Y, Takahashi J, Sugiyama K (2020) Effect of astaxanthin on the expression and activity of aquaporin-3 in skin in an in-vitro study
We validated these data using the antifolate-specific TS inhibitor raltitrexed 33
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Under OS, HIF-1 is stabilized via nitrogen oxide (NOX)/ROS, which upregulates glycolytic enzymes (SLC2A1 and HK) and inhibits mitochondrial respiration via PDK1 activation [222]
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