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Affecting over 25% of American adults and 25%30% of the global population, this multimorbidity comprises five stages with escalating mortality risk: stages 01 (metabolic dysfunction without significant target organ impairment), stages 23 (early cardiovascular and kidney injury), and stage 4 (severe cardiovascular events or kidney failure) ( For this review, we searched PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang Data up from January 2010 to December 2025

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Drugs Exp Clin Res 1994;20:169-76