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Lastly, to evaluate the robustness of the associations detected, we additionally included data collected from NESDA subjects still available at 6-year follow-up by pooling all observations (N = 4141) in a unified mixed model with two random factors (one for the family effect and one for the repeated observations from the same subject over time)
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Prespecified secondary outcomes included the first occurrence of an expanded composite cardiovascular outcome (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, revascularization [coronary or peripheral], and hospitalization for unstable angina or heart failure), an additional composite outcome (death from all causes, nonfatal myocardial infarction, or nonfatal stroke), the individual components of the composite outcomes, retinopathy complications, and new or worsening nephropathy
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