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Several factors explain the lack of approval: insufficient clinical trials (no completed Phase 3 trials for most indications), safety concerns (FDA has identified specific adverse events), commercial considerations (patent status affects development investment), regulatory pathway (approval requires specific, rigorous documentation), and competition (Tesamorelin already approved for related indication)

This long half-life is what makes once-weekly dosing possible

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Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

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