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placebo in approximately 17,500 people with overweight or obesity and established CVD with a follow-up of approximately 5 years (85)
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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis
Dehydration: Alcohol is a diuretic, meaning it can lead to dehydration
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